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. 2012 Apr 26;7(4):e35801. doi: 10.1371/journal.pone.0035801

Table 1. Beta-cell proliferation and number of total cells evaluated in sorted human beta-cells and non-sorted dispersed islet cells cultured on 3 different matrices in control medium or with Liraglutide and/or conditioned medium (n = 7).

Sorted beta-cells Non-sorted cells
Pooled treatmentsa Control Lira CM CM+Lira
% BrdU+/Ins+ BCEC 0.034±0.019 0.017±0.008 0.082±0.034 * 0.042±0.014 0.027±0.014
804 G 0.015±0.004 0.032±0.026 0.011±0.005 0.049±0.029 0.186±0.088
HTB9 0.097±0.082 0.028±0.025 0.047±0.034 0.097±0.040 0.035±0.024
Sorted beta-cells Non-sorted cells
Number of cells counted Total cells 85'412 525'001
Beta cells 84'283 232'826
BrdU+/Ins+ 22 104
% BrdU+/Ins+ Pooled matrices and treatments 0.051±0.020 0.055±0.011
a

For each matrix, the numbers of proliferating beta-cells were pooled from dishes treated with control media ±Liraglutide or condit.media ± Liraglutide.

*

represents p<0.05 as tested by Mann-Whitney.

CM, conditioned medium; Lira, Liraglutide; BCEC, bovine corneal endothelial cell; 804 G, rat bladder carcinoma; HTB9, human bladder carcinoma.