Figure 4. PAI-1 genetic deficiency is associated with reduced acute radiation-induced intestinal vascular injury.

Intestinal vasculature was visualized by CD31 staining (red) and computerized with confocal microscopy imaging. Nuclei were counterstained with Sytox Green (A). Representative images of intestinal vasculature 24 hours after irradiation in Wt and PAI-1 −/− mice (B). Quantitative assessment of vasculature integrity 24 hours after 19 Gy (C). (n = 6 mice/group) # p<0.05.