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. 2012 Apr 27;7(4):e36108. doi: 10.1371/journal.pone.0036108

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Mancini et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Median CD4⁺ cells count (upper panel) and provirus levels (lower panel) of the 250 virtual patients during the 48 weeks treatment period. In each panel we show the different STI tested in this study, the optimal therapy and the continuous therapy. The levels of provirus seem to be responsible for the failure of STI treatment as much as the CD4⁺ cells count. The “4 Weeks On/4 Weeks Off" schedule has the worst survival curve because of the high level of provirus even though it has a CD4⁺ cells count comparable to that of the “Week On/Week Off" STI.