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. 2012 Apr 27;7(4):e36316. doi: 10.1371/journal.pone.0036316

Figure 3. c-Fos expression and Fluorescent staining of Caudate Putamen in sIL-2Rs treated mice.

Figure 3

Photomicrographs of brain sections showing Fos-like immunoreactive cells in the caudate–putamen of mice receiving single injections of (A) saline, (B) sIL-2Rα (1 µg, s.c.), and (C) sIL-2Rβ (2 µg, s.c.). (D) Histogram showing the number (mean ± S.E.M.) of Fos-positive cells in the caudate–putamen after administration of saline or single injections of sIL-2Rα or sIL-2Rβ. (E) Histogram showing the number (mean ± S.E.M.) of Fos-positive cells counted within the indicated subterritories of caudate–putamen after administration of saline or single injections of sIL-2Rα or sIL-2Rβ (n = 4). Insert reflects regions sampled for counting Fos-positive cells in the dorsomedial (DM), dorsolateral (DL), central (CT), ventrolateral (VL) and ventromedial (VM) aspects of the caudate–putamen. Photomicrographs showing deposits of sIL-2Rα or sIL-2Rβ in caudate–putamen after administration of (F) saline or single injections of (G) sIL-2Rα and (H) sIL-2Rβ. Photomicrograph of omission control (I). Photomicrographs showing merged c-Fos and Fluorescent staining in sIL-2Rα treated mice (J) and sIL-2Rβ treated mice (K). [Arrow head: - Fluorescent staining; Arrow: - c-fos staining].