Table 1. Effect of various doses of sIL-1R1 on different open field behaviors.
Parameter | Saline | sIL-1R1 µg | sIL-1R 2 µg | sIL-1R 4 µg | sIL-1R 8 µg | f | p |
Locomotion (cm) | 6624.08±3198.82 | 7762.83±3394.46 | 7518.11±3540.1 | 7393.47±1909.66 | 4499.7±2113.78 | f (4, 34) = 1.83 | 0.15 |
Rearing Episodes (#) | 40.3±21.9 | 44.43±18.4 | 37.43±12.4 | 37.7±18.24 | 36.2±26.62 | f (4, 34) = 0.19 | 0.94 |
Turning | 29.5±13.91 | 33±11.87 | 35±17.37 | 30.88±10.04 | 21.66±13.93 | f (4, 34) = 0.91 | 0.47 |
Sniffing (sec) | 461.5±135.41 | 389.6±77 | 415.75±91.14 | 455±107.53 | N/A | f (3,12) = 0.46 | 0.71 |
Head Bobbing | 36.33±3.78 | 37±17.8 | 14.2±19 | 32±31.66 | 3±4.24 | f(3,14) = 1.12 | 0.37 |
Vertical Stereotypy Moves | 36.25±37.03 | 36±24.74 | 15.5±3.31 | 42.67±23.11 | N/A | f (3,12) = 0.82 | 0.5 |
Vertical Stereotypy Episodes | 16.25±16.04 | 15.8±10.23 | 7±1.63 | 18.67±9.01 | N/A | f (3,12) = 0.87 | 0.48 |
Table shows effects of various doses of single injection of sIL-1R1 on various behaviors in open field testing. Effects was considered significance if p<0.05.