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Influence of Aire deficiency on female fertility. Wild-type (WT) and Aire-deficient (KO) mice were monitored across two consecutive litters as described in Materials and Methods. A) Percentage of WT control and KO mice giving rise to viable litters. B) Litter size. Each circle represents the litter size of an individual dam. Bars represent the median. ***P < 0.001 by chi-square analysis.
