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Ovarian phenotype in parous Aire-deficient (KO) mice. Mice were followed for two consecutive litters, and at euthanization, ovaries were harvested and processed for histological analysis. A) Percentage of KO and wild-type (WT) mice with intact and depleted follicular reserves. B–D) Histological sections of ovaries from representative KO (B and C) and WT (D) mice exhibiting follicular loss (B) and intact follicles (C and D). ND, nondetected. Original magnification ×100.
