Table 1. pKa of selected VDE residues.
Residue | pKa | std |
ASP86 | 5.0 | 0.1 |
ASP98 | 5.3 | 0.2 |
ASP117 | 5.3 | 0.3 |
HIS168 | 7.0 | 0.3 |
ASP206 | 5.2 | 0.1 |
pKa values of all ionizable residues are shown in Table S1. Here are reported the ones identified as putatively responsible of the pH dependent activation, having pKa between 5 and 7 in VDEpH7.