Table 2. Correlations of secondary measures with MHFMS and age for SMA subjects.
MHFMS | Age | |
Age | 0.07 (p = 0.45) | |
BMI z-score | 0.17 (p = 0.09) | 0.12(p = 0.20) |
FVC % predicted | 0.70 (p<0.001) | −0.14(p = 0.31) |
10 meter walk | −0.28 (p = 0.13) | −0.36(p = 0.045) |
Of the secondary outcome measures, only forced vital capacity (FVC) significantly correlated with the primary outcome measure – the Modified Hammersmith Motor Function Scale. While BMI is thought to have a strong effect on function in individuals affected by SMA, the correlation did not reach significance here. Not surprisingly, FVC and walking were negatively correlated with age.