Table 1. Characteristics of the examined proteins.

	TP		ALB		NAP		IgG *	IgA *	IgM *	IgE *
	GWAS	Replication	GWAS	Replication	GWAS	Replication
No.	9,090	1,626	9,103	1,607	9,077	1,629	1,794	1,675	1,649	549
M±S.D a	7.10±0.50	7.06±0.73	4.25±0.35	4.00±0.51	2.85±0.42	3.07±0.57	1.44±0.61	0.27±0.15	0.11±0.07	1306.54±5598.06
Age b	69.52±10.44	59.52±15.43	69.52±10.44	59.54±15.39	69.51±10.44	59.48±15.52	59.70±15.46	59.38±15.73	59.42±15.57	62.54±18.61
Female %	37.45	45.08	37.41	45.12	37.46	45.12	55.30	54.57	54.88	63.93
BMI b	22.91±3.45	23.31±5.67	22.91±3.45	23.34±5.69	22.91±3.45	23.29±5.67	23.17±5.00	23.20±5.09	23.19±5.07	22.73±4.22
Smokers %	42.11	51.91	42.11	52.15	42.05	51.81	51.90	51.82	52.27	48.63
Drinkers %	29.37	51.97	29.37	52.08	29.40	51.81	51.00	50.81	50.82	41.35

^aM±S.D: mean value±standard deviation of each protein is indicated in g/dl except for IgE, which is indicated as IU/ml.

^bAge and body mass index (BMI) are indicated as mean values±standard deviation.

^*Log-transformed values were applied in the analysis.

Abbreviations: GWAS: genome-wide association study, TP: total protein, ALB: albumin, NAP: non-albumin protein.