Table 3. Association of the SNPs in the GWAS of the NAP with immunoglobulin isotypes.

SNP	Gene	IgG			IgA			IgM			IgE
		Effect a (s.e)	P b	%EV	Effect a (s.e)	P b	%EV	Effect a (s.e)	P b	%EV	Effect a (s.e)	P b	%EV
rs4985726	TNFRSF13B	0.071 (0.022)	1.4×10−3	0.51	0.049 (0.030)	0.099	–	−0.090 (0.032)	5.9×10−3	0.40	0.039 (0.064)	0.54	–
rs3803800	TNFSF13	−0.074 (0.024)	2.2×10−3	0.47	−0.086 (0.031)	6.2×10−3	0.39	−0.082 (0.034)	0.018	0.29	−0.117 (0.067)	0.080	–
rs11552708	TNFSF13	0.067 (0.022)	2.3×10−3	0.46	0.072 (0.029)	0.013	0.31	0.078 (0.032)	0.014	0.31	0.059 (0.060)	0.33	–
rs10007186	ANXA3	−0.018 (0.022)	0.42	–	−0.063 (0.030)	0.036	0.20	−0.078 (0.033)	0.019	0.27	0.200 (0.057)	4.9×10−4	2.02

^aThe effect of the minor alleles on the standardized values.

^b P-values for the associations of SNPs with each normalized immunoglobulin isotype obtained by using a linear regression model.

Abbreviations: s.e: standard error, %EV: percentage of the explanatory variance.