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. 2012 Apr 27;7(4):e35013. doi: 10.1371/journal.pone.0035013

Figure 7. Percentage of PPI in IR-hCB1-/- mice under different conditions.

Figure 7

All values represent the mean±S.E.M. Panel A: reversibility of Dox-induced disruption of PPI. Two groups of IR-hCB1-/- mice have been randomly assigned to vehicle group (dotted color, n = 6) or Dox group (plain color, n = 7) and then tested for PPI (Exp. 1). Dox administration lasted 12 days, and extra 12 days served for the washout, after which the schedule was repeated by switching the treatments (i.e. Dox given to previous No-Dox treated mice, and vice versa) (Exp. 2). Panel B: Dox-induced disruption of PPI is antagonized by haloperidol (1 mg/kg i.p., 30 min before PPI session).