Table 2. Hazard ratio of total and disease specific causes of mortality according to telomere length.
End Point | 1st vs 4th quartile | 2nd vs 4th quartile | 3rd vs 4th quartile | 1–3 versus 4th quartile |
Total Mortality | 1.20 (0.90, 1.61) | 1.18 (0.88, 1.59) | 1.48 (1.12, 1.96) | 1.29 (1.01, 1.64) |
Cancer Mortality | 1.43 (0.94, 2.16) | 1.35 (0.88, 2.07) | 1.65 (1.10, 2.49) | 1.48 (1.04, 2.11) |
Lung Cancer Mortality | 1.40 (0.83, 2.38) | 1.53 (0.91, 2.60) | 1.51 (0.89, 2.56) | 1.48 (0.94, 2.33) |
CVD Mortality | 2.09 (0.85, 5.12) | 1.95 (0.79, 4.84) | 2.19 (0.90, 5.33) | 2.08 (0.94, 4.61) |
Respiratory Mortality | 1.69 (0.57, 5.06) | 1.59 (0.52, 4.86) | 3.02 (1.10, 8.32) | 2.09 (0.81, 5.36) |
Adjustments were made for age, sex, smoking status (i.e. sustained smokers, intermittent quitters, quitters). Inclusion of other variables such as FEV1% predicted, body mass index and pack years of smoking made no significant differences to the results.