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. Author manuscript; available in PMC: 2012 Oct 26.
Published in final edited form as: Nature. 2012 Mar 28;484(7395):538–541. doi: 10.1038/nature10965

Fig. 3.

Fig. 3

Pausing of elongating ribosomes due to SD-aSD interaction. a, Two models could account for the excess ribosome density at internal SD-like sequences. b, Ribosome occupancy of lacZ mRNA translated by wildtype ribosome. Like other genes translated by the wildtype ribosome, the ribosome occupancy pattern along lacZ is correlated with the presence of SD-like sequences (left), and not with the orthogonal SD sequence (O-SD, right). c, Ribosome occupancy of lacZ mRNA translated by orthogonal ribosome (O-ribosome). Unlike other genes in the same cells, the specialized O-SD-lacZ has ribosome pausing at internal O-SD-like sequences (right), and not at SD-like sites (left).