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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Feb 22;1822(6):942–951. doi: 10.1016/j.bbadis.2012.02.012

Fig. 5.

Fig. 5

Microarray analysis reveals a broad impact of c-Met-deficiency on the critical signaling pathways associated with fibrotic disease. (A) Unsupervised hierarchical cluster analyses of isolated hepatocytes at 1 w of injury phase. A total of 406 differentially expressed genes was identified using Bootstrap t-test (P-value < 0.01) (B) Top signaling pathways in Metfl/fl;Alb-Cre+/− hepatocytes as determined by GeneGo analysis. (C) Hierarchical cluster analysis during injury phase (1 d, 1 w, 2 w, 3 w). A total of 680 differentially expressed genes in Metfl/fl;Alb-Cre+/− livers were identified (FDR ≤ 0.05; fold change ≥2). Note a clear separation of both genotypes and different time points. (D) Top signaling pathways in Metfl/fl;Alb-Cre+/− livers as determined by GeneGo analysis.