Testing the impact of purified secondary metabolites on C. albicans DAY185 hyphae formation. Freshly inoculated cells were treated with A) vehicle only (DMSO), B) farnesol (50 μM), C) waikialoid A (1) (50 μM), D) waikialide A (15) (50 μM), and incubated for 6 h prior to visualization by phase contrast microscopy (magnification ×200). Note the significant network of hyphal growth in the vehicle control, which is significantly reduced or absent from nearly all cells in the treatment groups. The effects of addition doses of these compounds are shown in the Supporting Information, Figure S41.