Table 3.
Inhibition of C. albicans biofilm formation and cell growth
| Compound | IC50a of biofilm inhibition (μM) | MICb of growth inhibition (μM) |
|---|---|---|
| 1 | 1.4 ± 0.2 | >200 |
| 2 | 108.6 ± 3.7 | >200 |
| 3 | 93.5 ± 3.6 | >200 |
| 5 | 97.3 ± 5.5 | >200 |
| 6 | 55.2 ± 2.4 | >200 |
| 7 | 43.3 ± 3.5 | >200 |
| 14 | 46.3 ± 1.6 | >200 |
| 15 | 32.4 ± 2.0 | >200 |
| 16 | 97.0 ± 2.1 | >200 |
| farnesol | 128.6 ± 2.6 | >200 |
a
IC50 expressed as the concentration of compound corresponding to a 50% reduction of C. albicans biofilm formation
b
MIC values were defined as the lowest concentration causing ≥80% reduction in the metabolic activity of C. albicans as determined by conversion of XTT to its colored product