Table II.
Within Peak voxel values and coordinates for whole‐brain voxelwise statistical parametric maps of one‐way t‐tests within the Control Group (N = 21) and OTCD Group (N = 19)
| Area | Talairach Coordinates | T‐statistic | Uncorrected P‐value | FWE corr. P‐value | |||
|---|---|---|---|---|---|---|---|
| X | Y | Z | |||||
| Control group | |||||||
| Cluster 1 | 51744 mm3 | ||||||
| R. Inf. Parietal Lob. | 37 | −47 | 42 | 10.4 | 5.06E‐13 | 6.42E‐08 | |
| L. Precuneus | −15 | −66 | 45 | 9.54 | 6.20E‐12 | 6.13E‐07 | |
| L. Inf. Parietal Lob. | −35 | −48 | 37 | 9.48 | 7.37E‐12 | 7.15E‐07 | |
| R. Sup. Parietal Lob. | 11 | −64 | 49 | 9.17 | 1.77E‐11 | 1.57E‐06 | |
| L. Inf. Parietal Lob. | −46 | −45 | 41 | 8.99 | 3.01E‐11 | 2.52E‐06 | |
| L. Mid. Occipital G. | −27 | −66 | 26 | 8.3 | 2.30E‐10 | 1.55E‐05 | |
| Cluster 2 | 42208 mm3 | ||||||
| L. Claustrum | −29 | 15 | 5 | 8.94 | 3.49E‐11 | 2.88E‐06 | |
| L. SMA | 0 | 13 | 45 | 8.39 | 1.75E‐10 | 1.21E‐05 | |
| L. Mid. Frontal G. | −22 | −1 | 54 | 8.06 | 4.82E‐10 | 2.98E‐05 | |
| L. Mid. Frontal G. | −44 | 18 | 36 | 8.05 | 4.83E‐10 | 2.98E‐05 | |
| L. Mid. Frontal G. | −28 | −4 | 52 | 8 | 5.68E‐10 | 3.45E‐05 | |
| L. Pallidum | −18 | 2 | 8 | 7.93 | 7.02E‐10 | 4.16E‐05 | |
| L. Precentral G. | −38 | −3 | 36 | 7.6 | 1.91E‐09 | 1.01E‐04 | |
| L. Precentral G. | −38 | −1 | 32 | 7.6 | 1.94E‐09 | 1.02E‐04 | |
| L. Inf. Frontal G. (p. Opercularis) | −48 | 6 | 22 | 7.36 | 4.04E‐09 | 1.95E‐04 | |
| L. SMA | −5 | −1 | 56 | 6.87 | 1.82E‐08 | 7.28E‐04 | |
| Cluster 3 | 25400 mm3 | ||||||
| R. Sup. Frontal G. | 22 | 2 | 57 | 8.48 | 1.36E‐10 | 9.67E‐06 | |
| R. Inf. Frontal G. (p. Triangularis) | 43 | 24 | 32 | 8.29 | 2.35E‐10 | 1.57E‐05 | |
| R. Mid. Frontal G. | 34 | 29 | 36 | 8.09 | 4.41E‐10 | 2.75E‐05 | |
| R. Mid. Frontal G. | 41 | 19 | 39 | 7.96 | 6.38E‐10 | 3.82E‐05 | |
| R.Precentral G. | 37 | 0 | 45 | 7.21 | 6.38E‐09 | 2.91E‐04 | |
| R.Precentral G. | 47 | 2 | 36 | 6.91 | 1.61E‐08 | 6.53E‐04 | |
| R. Mid. Frontal G. | 38 | 41 | 25 | 6.83 | 2.07E‐08 | 8.13E‐04 | |
| Cluster 4 | 5952 mm3 | ||||||
| L. Mid. Orbital G. | −27 | 42 | −5 | 8.17 | 3.45E‐10 | 2.22E‐05 | |
| L. Mid. Orbital G. | −34 | 47 | 6 | 7.54 | 2.32E‐09 | 1.20E‐04 | |
| Cluster 5 | 4064 mm3 | ||||||
| R. Claustrum | 27 | 19 | 6 | 8.09 | 4.35E‐10 | 2.72E‐05 | |
| R. Putamen | 17 | 3 | 10 | 7.14 | 7.86E‐09 | 3.49E‐04 | |
| Cluster 6 | 2728 mm3 | ||||||
| L. Inf. Temporal G. | −47 | −55 | −9 | 7.73 | 1.28E‐09 | 7.09E‐05 | |
| Cluster 7 | 4048 mm3 | ||||||
| R. Cerebelum (VIII) | 32 | −58 | −47 | 7.37 | 3.89E‐09 | 1.88E‐04 | |
| R. Cerebelum (Crus 1) | 30 | −63 | −21 | 7.36 | 4.07E‐09 | 1.96E‐04 | |
| R. Cerebelum (Crus 1) | 38 | −57 | −27 | 6.72 | 2.94E‐08 | 1.11E‐03 | |
| Cluster 8 | 2464 mm3 | ||||||
| L. Cerebelum (Crus 1) | −27 | −58 | −31 | 7.21 | 6.38E‐09 | 2.91E‐04 | |
| L. Cerebelum (VII) | −28 | −59 | −40 | 6.67 | 3.43E‐08 | 1.26E‐03 | |
| Cluster 9 | 1744 mm3 | ||||||
| R. Inf. Temporal G. | 56 | −46 | −8 | 6.99 | 1.27E‐08 | 5.32E‐04 | |
| Cluster 10 | 440 mm3 | ||||||
| R. Caudate Nucleus | 14 | 3 | 10 | 6.7 | 3.15E‐08 | 1.17E‐03 | |
| R. Caudate Nucleus | 8 | 3 | 4 | 6.65 | 3.62E‐08 | 1.33E‐03 | |
| R. Caudate Nucleus | 14 | 10 | 7 | 6.47 | 6.50E‐08 | 2.20E‐03 | |
| Cluster 11 | 256 mm3 | ||||||
| L. Caudate Nucleus | −16 | −1 | 17 | 6.53 | 5.31E‐08 | 1.85E‐03 | |
| L. Caudate Nucleus | −16 | −5 | 18 | 6.5 | 5.93E‐08 | 2.03E‐03 | |
| L. Caudate Nucleus | −12 | 5 | 8 | 6.23 | 1.36E‐07 | 4.17E‐03 | |
| L. Caudate Nucleus | −16 | 3 | 15 | 6.1 | 2.08E‐07 | 5.99E‐03 | |
| L. Caudate Nucleus | −12 | 8 | 5 | 6.04 | 2.49E‐07 | 7.00E‐03 | |
| L. Caudate Nucleus | −12 | −3 | 13 | 5.96 | 3.26E‐07 | 8.80E‐03 | |
| OTCD group | |||||||
| Cluster 1 | 12832 mm3 | ||||||
| R. Inf. Frontal G. (p. Triangularis) | 41 | 30 | 23 | 8.85 | 4.49E‐11 | 3.60E‐06 | |
| R. Mid. Frontal G. | 36 | 34 | 15 | 8.08 | 4.44E‐10 | 2.77E‐05 | |
| R. Mid. Frontal G. | 37 | 57 | 6 | 7.36 | 4.02E‐09 | 1.94E‐04 | |
| Cluster 2 | 9296 mm3 | ||||||
| R. Sup. Medial G. | 2 | 15 | 44 | 8.62 | 8.93E‐11 | 6.65E‐06 | |
| Cluster 3 | 5984 mm3 | ||||||
| R. Inf. Parietal Lob. | 35 | −51 | 42 | 8.08 | 4.41E‐10 | 2.75E‐05 | |
| Cluster 4 | 7176 mm3 | ||||||
| L. Cerebelum (Crus 1) | −29 | −58 | −32 | 7.88 | 8.08E‐10 | 4.71E‐05 | |
| L. Cerebelum (Crus 2) | −36 | −64 | −47 | 7.73 | 1.28E‐09 | 7.07E‐05 | |
| Cluster 5 | 6512 mm3 | ||||||
| R. Mid. Frontal G. | 24 | −1 | 51 | 7.5 | 2.59E‐09 | 1.32E‐04 | |
| R.Precentral G. | 36 | 0 | 43 | 6.85 | 1.99E‐08 | 7.86E‐04 | |
| Cluster 6 | 3736 mm3 | ||||||
| L. Mid. Frontal G. | −26 | 0 | 45 | 7.44 | 3.11E‐09 | 1.55E‐04 | |
| L. Sup. Frontal G. | −24 | −2 | 65 | 6.12 | 1.94E‐07 | 5.64E‐03 | |
| Cluster 7 | 5664 mm3 | ||||||
| L. Inf. Parietal Lob. | −35 | −56 | 42 | 7.38 | 3.82E‐09 | 1.85E‐04 | |
| L. Inf. Parietal Lob. | −52 | −52 | 40 | 6.45 | 6.79E‐08 | 2.29E‐03 | |
| L. Inf. Parietal Lob. | −48 | −47 | 42 | 6.33 | 1.02E‐07 | 3.25E‐03 | |
| L. Sup. Parietal Lob. | −24 | −70 | 44 | 5.91 | 3.72E‐07 | 9.87E‐03 | |
| Cluster 8 | 1648 mm3 | ||||||
| R. Cerebelum (Crus 1) | 34 | −67 | −27 | 7.25 | 5.64E‐09 | 2.61E‐04 | |
| Cluster 9 | 5736 mm3 | ||||||
| L. Inf. Frontal G. (p. Opercularis) | −49 | 12 | 35 | 7.08 | 9.49E‐09 | 4.12E‐04 | |
| L. Inf. Frontal G. (p. Triangularis) | −42 | 22 | 31 | 7.05 | 1.05E‐08 | 4.49E‐04 | |
| L. Precentral G. | −48 | 1 | 31 | 6.73 | 2.82E‐08 | 1.07E‐03 | |
| L. Precentral G. | −42 | −2 | 47 | 6.11 | 2.01E‐07 | 5.84E‐03 | |
| Cluster 10 | 368 mm3 | ||||||
| L. Sup. Parietal Lob. | −15 | −66 | 46 | 6.61 | 4.23E‐08 | 1.52E‐03 | |
These testing for activation correlated with an increase in working memory load. Clusters reported are for voxels surviving FWE corrected P‐value < 0.01, minimum of 240 mm3 per cluster and peaks 4‐mm apart.