Table 3.
Statistical summary for menthol intensity estimates during menthol application
| Menthol sensation | Time effect | Menthol stimulation effect | Interaction time by stimulation | |||
|---|---|---|---|---|---|---|
| Overall | Pairwise comparisons | |||||
| ML versus MM | ML versus MH | MM versus MH | ||||
| P value (F value) | P value (F value) | P value (F value) | ||||
| Odor (LN) | <0.0001 (6.27) | <0.0001 (14.38) | P = 0.22 (t 69 = 1.23) | P = 0.09 (t 69 = −1.69) | P = 0.62 (t 69 = −0.50) | 0.04 (1.42) |
| Odor (HN) | <0.0001 (6.49) | <0.0001 (10.53) | P = 0.86 (t 62 = 0.17) | P = 0.80 (t 62 = 0.25) | P = 0.94 (t 62 = 0.07) | 0.002 (1.79) |
| Cooling (LN) | 0.002 (2.44) | <0.0001 (35.56) | P = 0.05 (t 69 = −1.98) | P = 0.005 (t 69 = −2.94) | P = 0.31 (t 69 = −1.01) | 0.26 (1.14) |
| Cooling (HN) | 0.004 (2.34) | <0.0001 (17.62) | P = 0.87 (t 62 = 0.17) | P = 0.96 (t 62 = 0.05) | P = 0.83 (t 62 = 0.22) | 0.08 (1.32) |
| Pain (LN) | 0.10 (1.52) | 0.005 (4.67) | P = 0.40 (t 69 = 0.85) | P = 0.09 (t 69 = −1.72) | P = 0.01 (t 69 = −2.63) | 0.52 (0.97) |
| Pain (HN) | 0.80 (0.68) | 0.0003 (7.18) | P = 0.45 (t 62 = 0.76) | P = 0.014 (t 62 = −2.52) | P = 0.002 (t 62 = −3.23) | 0.61 (0.93) |
P values were derived from a linear mixed model for repeated measures; statistical significance was evaluated at P < 0.05. LN, low nicotine; HN, high nicotine
ML condition menthol-low, MM condition menthol-medium, MH condition menthol-high
The significant overall stimulation effect is mainly caused by the menthol placebo condition. The comparisons with the menthol placebo condition are not shown