Table 3.

Summary of binding of key IL-21 mAbs to various forms of IL-21 and to peptides derived from IL-21

		*Direct ELISA						**Western blot
mAb clone	Epitope bin	Human IL-21	IL-21 mutein-Fc (Q116D/I119D)	Pep #1	Pep #2	Pep #3	Pep #4	Human IL-21	Cynomolgus IL-21	Mouse IL-21
362.78	1	++	+	0	0	0	0	++	++	0
362.597	1	+++	++	0	0	0	0	++	++	0
366.552	“1/2”	+++	0	0	0	0	++	+++	+++	+++
366.328	2	+++	+++	0	0	0	0	+	+	0
362.75	2	+++	0	0	0	0	+++	+++	+++	+++
366.345	3	+++	++	0	0	0	0	0	0	0