Table 3.
*Direct ELISA | **Western blot | |||||||||
mAb clone | Epitope bin | Human IL-21 | IL-21 mutein-Fc (Q116D/I119D) | Pep #1 | Pep #2 | Pep #3 | Pep #4 | Human IL-21 | Cynomolgus IL-21 | Mouse IL-21 |
362.78 | 1 | ++ | + | 0 | 0 | 0 | 0 | ++ | ++ | 0 |
362.597 | 1 | +++ | ++ | 0 | 0 | 0 | 0 | ++ | ++ | 0 |
366.552 | “1/2” | +++ | 0 | 0 | 0 | 0 | ++ | +++ | +++ | +++ |
366.328 | 2 | +++ | +++ | 0 | 0 | 0 | 0 | + | + | 0 |
362.75 | 2 | +++ | 0 | 0 | 0 | 0 | +++ | +++ | +++ | +++ |
366.345 | 3 | +++ | ++ | 0 | 0 | 0 | 0 | 0 | 0 | 0 |