Table 1.

Study groups

Study group	Route of scrapie infection	Treatment	Number of animals
negative controls	none	standard diet (vehicle)	15
i.c. uninfected-treated	intracerebral	CHF5074-medicated diet	8
i.p. uninfected-treated	intraperitoneal	CHF5074-medicated diet	8
i.c. infected-controls	intracerebral	standard diet (vehicle)	15
i.c. infected-treated	intracerebral	CHF5074-medicated diet	15
i.p. infected-controls	intraperitoneal	standard diet (vehicle)	15
i.p. infected-treated	intraperitoneal	CHF5074-medicated diet	15

Mice were randomly divided into groups depending on the route of scrapie infection and on the type of treatment (vehicle or CHF5074). The concentration of CHF5074 in the medicated diet was 375 ppm.