Table 2.
Genotypic distribution and allele frequencies of the studied polymorphisms
| Genotype/allele frequencies, n (%) | AD (n = 99) | MCI (n = 48) | p value |
| APOE-ε4 dose | |||
| ε4 (-) | 43 (43.4) | 34 (70.8) | 0.004 |
| 1 × ε4 | 46 (46.5) | 10 (20.8) | |
| 2 × ε4 | 10 (10.1) | 4 (8.3) | |
| ε4 (-) | 43 (43.4) | 34 (70.8) | 0.003 |
| ε4 (+) | 56 (56.6) | 14 (29.2) | |
| CYP46-rs754203 | |||
| C/C | 18 (18.2) | 7 (14.6) | 0.55 |
| C/T | 41 (41.4) | 17 (35.4) | |
| T/T | 40 (40.4) | 24 (50) | |
| C allele frequency | 0.39 | 0.32 | 0.4 |
| T allele frequency | 0.61 | 0.68 | |
| CYP46-i2 new | |||
| C/C | 83 (83.8) | 37 (77.1) | 0.4 |
| C/T | 12 (12.1) | 10 (20.8) | |
| T/T | 4 (4.1) | 1 (2.1) | |
| C allele frequency | 0.9 | 0.875 | 0.8 |
| T allele frequency | 0.1 | 0.125 | |
| PRNP-codon 129 | |||
| M/M | 37 (37.4) | 19 (39.6) | 0.96 |
| M/V | 51 (51.5) | 24 (50) | |
| V/V | 11 (11.1) | 5 (10.4) | |
| M allele frequency | 0.63 | 0.65 | 1.0 |
| V allele frequency | 0.37 | 0.35 | |
| PRND AD (n = 64) MCI (n = 28) | |||
| Codon 26 | |||
| C/C | 58 (90.6) | 25 (89.3) | 1.0 |
| C/T | 6 (9.4) | 3 (10.7) | |
| Codon 56 | |||
| C/C | 63 (98.4) | 26 (92.9) | 0.2 |
| C/T | 1 (1.6) | 2 (7.1) | |
| Codon 174 | |||
| C/C | 15 (23.4) | 6 (21.4) | 0.9 |
| C/T | 31 (48.5) | 13 (46.4) | |
| T/T | 18 (28.1) | 9 (32.2) | |
| C allele frequency | 0.48 | 0.45 | 1.0 |
| T allele frequency | 0.52 | 0.55 | |
| 3′UTR | |||
| C/C | 20 (31.2) | 7 (25) | 0.8 |
| C/T | 30 (46.9) | 15 (53.6) | |
| T/T | 14 (21.9) | 6 (21.4) | |
| C allele frequency | 0.55 | 0.52 | 1.0 |
| T allele frequency | 0.45 | 0.48 | |
AD, Alzheimer disease; MCI, mild cognitive impairment