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. Author manuscript; available in PMC: 2012 Apr 29.
Published in final edited form as: J Am Chem Soc. 2012 Mar 16;134(12):5689–5696. doi: 10.1021/ja300839n

Figure 2.

Figure 2

Schematic for pinwheel-based extraction of DNA from whole blood. (Upper) Whole blood (800 nL) added to 12 μL of GdnHCl containing ~6.4 × 105 8-μm magnetic beads and exposed to the RMF for 90 s. The formed pinwheels disaggregate after the chaotrope solution (GdnHCl) is replaced with Tris-EDTA buffer (TE), which leads to release of the DNA within 90 s. (Lower) Electropherogram of PCR-amplified products from an aliquot of elution buffer following bead dispersal. Product (shaded peak) is the 389-bp fragment of the β-globin gene.