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. Author manuscript; available in PMC: 2012 Apr 29.
Published in final edited form as: J Am Chem Soc. 2012 Mar 16;134(12):5689–5696. doi: 10.1021/ja300839n

Figure 6.

Figure 6

Digital response associated with HIA: semiquantitative HIA, demonstrating a clear digital distinction between the presence of the target sequence at a low concentration, with nonspecific sequences at high concentration, and with no DNA present. (A, left) 104 copies of the 26-base PL target. (B, middle) 1010 copies of the 26-base noncomplementary sequence yielding a % Dark Area similar to (C, right) no DNA present. A total of 4 μL of beads and a low aperture setting were required to generate digital response (hence, the darkness of the image). Each error bar represents the standard deviation associated with n = 4.