Table 4.
SNPs Within or Near the SLC22A3-LPAL2-LPA Locus: Association With CFU and Myocardial Infarction in Framingham Heart Study
| SNP | Position (bp) | MAF | A1–A2 | MI risk allele* | Location Relative to Gene | Association with CFU | Association with MI* | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Beta (SE) | P value | HR (95% CI) | P value | |||||||
| SNPs with strongest associations with MI | rs569919 | 160687173 | 0.31 | C-T | C | Upstream | 0.15 (0.04) | 1.62 x10−4 | 0.71 (0.59–0.84) | 1.08×10−4 |
| rs394487 | 160698629 | 0.31 | C-T | C | Intronic | 0.16 (0.04) | 1.62 x10−5 | 0.74 (0.62–0.88) | 5.50×10−4 | |
| rs394468 | 160700902 | 0.31 | G-T | G | Intronic | 0.16 (0.04) | 1.22 x10−5 | 0.74 (0.62–0.87) | 4.94×10−4 | |
| rs377551 | 160701723 | 0.31 | G-A | G | Intronic | 0.16 (0.04) | 1.17 x10−5 | 0.73 (0.62–0.87) | 4.86×10−4 | |
| rs2661834 | 160770901 | 0.31 | C-T | C | Intronic | 0.17 (0.04) | 8.24 x10−6 | 0.75 (0.64–0.89) | 8.48×10−4 | |
| rs2063345 | 160780144 | 0.32 | A-G | A | Intronic | 0.17 (0.04) | 8.75 x10−6 | 0.75 (0.63–0.88) | 6.93×10−4 | |
| rs2174914 | 160783098 | 0.32 | G-C | G | Intronic | 0.17 (0.04) | 6.59 x10−6 | 0.74 (0.62–0.87) | 3.66×10−4 | |
| rs2457576 | 160785609 | 0.32 | G-C | G | Intronic | 0.17 (0.04) | 6.70 x10−6 | 0.74 (0.62–0.87) | 2.51×10−4 | |
| rs2457575 | 160788317 | 0.32 | A-G | A | Intronic | 0.17 (0.04) | 6.93 x10−6 | 0.74 (0.62–0.87) | 2.53×10−4 | |
| rs1567438 | 160799621 | 0.32 | T-C | T | Intronic | 0.16 (0.04) | 1.50 x10−5 | 0.73 (0.62–0.87) | 3.01×10−4 | |
| SNPs with strongest associations with CFU | rs402219 | 160709286 | 0.3 | A-G | A | Intronic | 0.19 (0.04) | 6.01×10−7 | 0.77 (0.65, 0.91) | 1.83×10−3 |
| rs443043 | 160709531 | 0.3 | G-C | G | Intronic | 0.19 (0.04) | 6.02×10−7 | 0.77 (0.65, 0.91) | 1.84×10−3 | |
| rs1018234 | 160716048 | 0.3 | C-T | C | Intronic | 0.19 (0.04) | 6.05×10−7 | 0.77 (0.65, 0.91) | 1.87×10−3 | |
| rs316244 | 160716555 | 0.3 | G-A | G | Intronic | 0.19 (0.04) | 6.07×10−7 | 0.77 (0.65, 0.91) | 1.88×10−3 | |
| rs1510229 | 160725659 | 0.3 | C-T | C | Intronic | 0.19 (0.04) | 5.22×10−7 | 0.76 (0.64, 0.90) | 1.41×10−3 | |
| rs420038 | 160728138 | 0.3 | C-T | C | Intronic | 0.19 (0.04) | 5.94×10−7 | 0.76 (0.65, 0.90) | 1.54×10−3 | |
| rs394352 | 160728385 | 0.3 | C-T | C | Intronic | 0.20 (0.04) | 4.92×10−7 | 0.75 (0.64, 0.90) | 1.20×10−3 | |
| rs440962 | 160731144 | 0.3 | G-A | G | Intronic | 0.19 (0.04) | 7.64×10−7 | 0.76 (0.64, 0.90) | 1.28×10−3 | |
| rs446926 | 160733746 | 0.3 | A-G | A | Intronic | 0.19 (0.04) | 8.70×10−7 | 0.76 (0.64, 0.90) | 1.21×10−3 | |
| rs1510225 | 160738253 | 0.3 | C-T | C | Intronic | 0.19 (0.04) | 8.85×10−7 | 0.76 (0.64, 0.90) | 1.20×10−3 | |
Analyses performed in a sample of 4,497 participants in FHS among whom 419 incident MI events occurred over 36 years of follow up. The HRs correspond to the minor allele; thus, HRs <1.0 denote that the major allele is associated with higher MI risk. SNP, single-nucleotide polymorphism; MAF, minor allele frequency; A1, major allele; A2, minor allele; CFU, colony forming unit; SE, standard error; MI, myocardial infarction; HR, hazards ratio.
SNPs in the upper part of the table are those with the strongest associations with MI, whereas SNPs in the lower part of the table are those with the strongest associations with CFU. Order of SNPs is by chromosomal position.