Table 2.
PXR antagonists
| Compound | Indications/Usage | IC50 | References |
|---|---|---|---|
| Et-743 | Antineoplastic Agent | 2 nM | [92] |
| Ketoconazole And Its Analogues (Fluconazole And Enilconazol) | Antifungal Agent | 20 μM | [239, 240] |
| Sulforaphane | Dietary Isothiocyanate | 12 μM | [261] |
| Coumestrol | Phytoestrogen | 12 μM | [262] |
| A-792611 | HIV Protease Inhibitor | 2 μM | [263] |
| Polychlorinated Biphenyls | Synthetic Hydrocarbon Compounds | 10uM | [264] |
| Camptothecin | Antineoplastic Agent | 0.58 μM | [90] |
| Ecteinascidin-743 (ET-743) | Antineoplastic Agent | 3 nM | [92] |
| Le unamide | Pyrimidine Synthesis Inhibitor | 6.8 μM | [265] |
| Itraconazole | Triazole Antifungal Agent | 8.96 μM | [265] |
| SPB03255 | Identified By Using Ligand-Based And Structure-Based (Docking) In Silica Methods | 5–25 μM | [265] |