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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2011 Dec 20;98(0):69–74. doi: 10.1016/j.prostaglandins.2011.12.003

Figure 4.

Figure 4

Activation of cPLA2 by Ang II and other vasoactive agents releases AA from tissue phospholipids (PLs). One or more metabolite(s) of AA generated via CYP1B1 stimulates NADPH oxidase activity and generates ROS, that in turn by stimulating one or more signaling molecules (ERK 1/2, p38MAPK and c-Src) results in hypertension and associated pathophysiological changes.