Table 2.
Agreement of Gleason patterns and scores assigned by two expert reviewers
| A. BIOPSY SPECIMENS (n=268)
| |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reviewer 2 | |||||||||
| 3+3=6 | 3+4=7 | 4+3=7 | 3+5=8 | 4+4=8 | 4+5=9 | 5+4=9 | 5+5=10 | ||
| Reviewer 1 | 3+3=6 | 83 | 14 | 4 | 0 | 0 | 0 | 0 | 0 |
|
| |||||||||
| 3+4=7 | 34 | 37 | 14 | 0 | 2 | 0 | 0 | 0 | |
| 4+3=7 | 3 | 12 | 16 | 0 | 8 | 0 | 0 | 0 | |
|
| |||||||||
| 3+5=8 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | |
| 4+4=8 | 1 | 1 | 3 | 0 | 3 | 1 | 0 | 0 | |
|
| |||||||||
| 4+5=9 | 1 | 1 | 7 | 0 | 9 | 3 | 1 | 0 | |
| 5+4=9 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 0 | |
|
| |||||||||
| 5+5=10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | |
| Weighted kappa for Gleason pattern: 0.59 (95% CI: 0.52, 0.66) | |||||||||
| Weighted kappa for total Gleason score: 0.56 (95% CI: 0.48, 0.63) | |||||||||
| Kappa for Gleason score ≤7 versus ≥8: 0.57 (95% CI: 0.47, 0.66) | |||||||||
| B. PROSTATECTOMY SPECIMENS (n=120)
| ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Reviewer 2 | ||||||||||
| 3+2=5 | 3+3=6 | 3+4=7 | 4+3=7 | 3+5=8 | 4+4=8 | 5+3=8 | 4=5=9 | 5+4=9 | ||
| Reviewer 1 | 3+2=5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
|
| ||||||||||
| 3+3=6 | 0 | 41 | 6 | 1 | 0 | 0 | 0 | 0 | 0 | |
|
| ||||||||||
| 3+4=7 | 0 | 14 | 26 | 9 | 0 | 2 | 0 | 0 | 0 | |
| 4+3=7 | 0 | 0 | 2 | 6 | 0 | 0 | 1 | 0 | 0 | |
|
| ||||||||||
| 3+5=8 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | |
| 4+4=8 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
| 5+3=8 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
|
| ||||||||||
| 4+5=9 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 0 | |
| 5+4=9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Weighted kappa for Gleason patterns: 0.53 (95% CI: 0.39, 0.67) | ||||||||||
| Weighted kappa for total Gleason score: 0.57 (95% CI: 0.44, 0.70) | ||||||||||
| Kappa for Gleason score ≤7 versus ≥8: 0.61 (95% CI: 0.47, 0.75) | ||||||||||