Table 5.

Multivariate analyses evaluating determinants of discordance between biopsy-derived Gleason patterns assigned by final (gold standard”) expert review and those documented in pathology reports

Determinants of disagreement	Any discordance	Discordance by two or more categories*
Diagnosis age:	OR (95% CI)	OR (95% CI)
<65 years	1.0 (reference)	1.0 (reference)
≥65 years	2.06 (1.45, 2.92)	2.84 (1.27, 6.35)
Race:
White	1.0 (reference)	1.0 (reference)
Black	1.23 (0.59, 2.55)	0.89 (0.36, 2.25)
Area, based measure of SES**
Low	1.0 (reference)	1.0 (reference)
High	1.15 (0.83, 1.60)	0.75 (0.38, 1.45)
Disease stage
Localized	1.0 (reference)	1.0 (reference)
Regional/Distant	2.78 (1.54, 5.02)	3.92 (1.47, 10.41)
PSA at diagnosis
<10 ng/ml	1.0 (reference)	1.0 (reference)
≥10 ng/ml	1.37 (0.67, 2.82)	2.41 (0.77, 7.53)
Not reported/missing	1.69 (0.78, 3.65)	2.81 (1.00, 7.95)
Facility type:
Freestanding laboratories	1.0 (reference)	1.0 (reference)
University hospitals	1.70 (1.16, 2.48)	1.17 (0.62, 2.23)
Large community hospitals	2.08 (1.37, 3.16)	1.63 (0.77, 3.44)
Small community hospitals	2.98 (1.73, 5.14)	2.54 (0.92, 7.02)

^*Gleason’s patterns were ranked in ascending order based on a total score followed by a primary pattern as shown in Tables 2–4. For example, 3+4=7 was followed by 4+3=7, followed by 3+5=8, followed by 4+4=8, tec.

^**Defined based on percent population in a census tract living below poverty level: low SES ≥10%, high SES <10%