Table 3.

Known Biological and Molecular Functions for bHLH Proteins by Fungal Group.

Group	Reported Members	Biological Function
F2	RTG1, RTG3, MGG_05709	Interorganelle communication between mitochondria, peroxisomes, and nucleus.
F3	CBF1, CBF1P, CaCBF1, AnBH1, CPF1	Chromosome segregation, methionine auxotrohpic growth, rRNA transcription, repression of penicillin biosynthesis, regulation of sulfur utilization, ribosome biogenesis, and glycolysis.
F4	TYE7, SAH-2, HMS1, SRE1, SRE2, CPH2, CAP1P	Sexual development, aerial hyphae development, hypoxic response, carbon catabolite transcription activation, regulation of glycolysis, ergosterol biosynthesis, heme biosynthesis, phospholipid biosynthesis.
F5	Q6MYV5	Nitrate assimilation, quinate utilization.
F6	PHO4, NUC-1, PalcA	Response to copper ion, regulate phosphate acquisition and metabolic process, promotes sexual development, represses asexual development.
F8	ESC1, devR	Sexual differentiation, sexual conjugation, development under standard growth conditions.
F10	YAS2	Alkane response.
F11	INO4, YAS1	Derepression of phospholipid synthesis, alkane response.
F12	INO2	Derepression of phospholipid synthesis.

Note.—No functional annotations were found for members of groups F1 and F7. Literature describing biological functions of the reported members of groups F2–F12 are cited in the manuscript.