Table 3.

Systemic diseases accompanied by generalized pruritus/urticaria

Liver diseases	Primary biliary cirrhosis
	Primary sclerosing cholangitis
	Extrahepatic cholestasis
	Heptatits B and C
Kidney diseases	Chronic kidney insufficiency
Hematologic diseases	Polycythemia vera
	Hodgkin disease
	Non-Hodgkin lymphomas
	Leukemias
	Myeloma Multiplex
	Iron deficiency
	Systemic mastocytosis
	Hypereosinophilic syndrome
	Myelodysplastic syndromes
Endocrine disorders	Diabetes
	Hyperthyroidism
	Hypothyroidism
	Hyperparathyroidism
Neurologic diseases (neuropathic pruritus)	Brain injury/tumor (frequently unilateral pruritus)
	Sclerosis multiplex
	Small fiber neuropathy
Solid tumors (paraneoplasic pruritus)
Carcinoid syndrome
Infectious diseases	HIV infection/AIDS
	Infestations

Adapted from Reich A et al. [48]