Table 2.
Three component Strecker reaction using aniline (1 mmol), benzaldehyde (1 mmol) and TMSCN (1.2 mmol) in presence of indium (10 mol%) in various solvents (30 min): solvent optimization
| Entry | Solvent | Yield (%)a |
|---|---|---|
| 1 | Water | 98 |
| 2 | THF | 34 |
| 3 | Ethanol | 56 |
| 4 | Toluene | 60 |
| 5 | Methanol | 68 |
| 6 | Dichloromethane | 61 |
| 7 | DMSO | 76 |
| 8 | THF/H2O (1:1) | 54 |
| 9 | Ethanol/H2O (1:1) | 71 |
aisolated yield