Table 3.
In vitro antibacterial and antifungal activities of compounds 7-12 by twofold serial dilution method
| Microorganisms | Minimum inhibitory concentration (MIC) (μg/mL) | |||||||
|---|---|---|---|---|---|---|---|---|
| 7 | 8 | 9 | 10 | 11 | 12 | Ciprofloxacin | Fluconazole | |
| Staphylococcus aureus | 50 | 12.5 | 6.25 | 25 | 200 | 100 | 25 | - |
| β-Heamolytic streptococcus | 50 | 6.25 | 25 | 25 | 100 | 200 | 25 | - |
| Micrococcus luteus | 6.25 | 6.25 | 25 | 25 | 200 | 200 | 12.5 | - |
| Bacillus subtilis | 50 | 12.5 | 25 | 25 | 200 | 200 | 12.5 | - |
| Salmonella typhii | 100 | 50 | 50 | 6.25 | 100 | 200 | 25 | - |
| Shigella flexneri | 200 | 100 | 6.25 | 6.25 | 25 | 100 | 12.5 | - |
| Vibreo cholerae | 100 | 25 | 6.25 | 12.5 | 50 | 100 | 25 | - |
| Escherichia coli | 50 | 25 | 50 | 12.5 | 50 | 100 | 25 | - |
| Pseudomonas aeruginosa | 25 | 100 | 6.25 | 12.5 | 100 | 50 | 25 | - |
| Klebsiella pneumonia | 25 | 6.25 | 25 | 200 | 6.25 | 6.25 | 12.5 | - |
| Aspergillus flavus | 50 | 50 | 6.25 | 200 | 50 | 100 | - | 12.5 |
| Aspergillus niger | 200 | 25 | 25 | 100 | 50 | 12.5 | - | 12.5 |
| Mucor indicus | 100 | 100 | 6.25 | 100 | 100 | 200 | - | 25 |
| Rhizopus arrhizus | 100 | 100 | 25 | 100 | 25 | 100 | - | 25 |
| Microsporum gypseum | 50 | 6.25 | 200 | 6.25 | 6.25 | 6.25 | - | 12.5 |