Table 2.
Comparison of FeNO values between groups in the 18 studies included
| Studies in Children (n = 8) | Studies in Adults (n = 11) | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (n = 4) |
Median (n = 2) |
Values not shown (n = 2) | Mean (n = 3) |
Median (n = 6) |
Values not shown (n = 2) | ||||||||||||||
| Hervás 2008 [8] | Hung 2007 [22] | Malmberg 2006 [21] | Saito 2004 [28] | Cardinale 2005 [11] | Cibella 2008 [12] | Marcucci 2007 [23] | Profita 2006 [13] | Prieto 2002 [29] | Prieto, 2002 [16] | Rolla 2007 [30] | Rouhos 2008 [31] | Kostikas 2008 [32] | Tanou 2009 [33] | Berlyne 2000 [14] | Gratziou 2008 [34] |
Olin 2004 [35] | Aronsson 2005 [36] | Mansson 2009 [37] | |
| FeNO Values | |||||||||||||||||||
| Atopic | 19 (1.21) | - | 14.6‡ | 33.3 (1.13) | - | 17.4 (5.5-95.2)* |
FeNO values not present§ |
- | - | - | 13.2† | - | - | 11 (6) | . | 16.5 (11.3-27.6) |
FeNO values not present§ |
||
| AR | 26.3 (1.04) | 24.68 (19.2) | - | - | 15.3 (9.4-31.0) |
19.1 (5.8-92.5)* |
25.1 (5.7-102.9)† |
DS: 63.1(1.26) OS: 30.2(1.27) | 24.5 (3.32) |
23.0 (11.6-43.6)* |
17.0 (12.5-23.0) |
20.5 (12.5-33) |
- | 12.5 (4.0-50.0) |
31.0 (16.0-50.5) |
||||
| NAR | - | - | - | - | - | 12.6 (2.8-71.8)* |
- | - | 16.1‡ | - | - | - | - | - | 19.2 (14.1-22.0) |
||||
| Healthy | 7.9 (0.96) | 9.44 (3.97) | 10.3‡ | 15.1 (1.14) | 5.9 (3.4-9.3) |
13.1 (3.0-71.0)* |
11.2 (5.0-31.5) ** |
12.6 (1.4) | 13.5 (0.9) |
15.5 † | 10.5 (7.0-13.0) |
9.5 (8.0-12.0) |
9 (7) | 3.8 (1.0-7.3) |
15.8 (11.9-21.4) |
||||
| Comparison of FeNO values between || | |||||||||||||||||||
| Atopic and Healthy | ↑↑ | - | ↑ | ↑↑ | - | ↑ | - | - | - | - | - | NS (↓) | - | - | NS (↑) | - | NS (↑) | - | - |
| AR and Healthy | ↑↑↑ | ↑↑↑ | - | - | ↑↑↑ | NS (↑) | ↑ | NS (↔) | ↑↑ | E:↑↑↑ NE:↑↑ |
↑↑ | NR (↑) | ↑↑ | ↑↑ | - | ↑↑↑ | NR (↑↑) | NS (↔) | ↑ |
| NAR and Healthy | - | - | - | - | - | NS (↓) | - | - | - | - | NS (↑) | - | - | - | - | - | NR (↑↑) | - | - |
| AR and Atopic | ↑ | - | - | - | - | NS (↑) | - | - | - | - | - | NR (↑↑) | - | - | - | - | ↑↑ | - | - |
| AR and NAR | - | - | - | - | - | ↑ | - | - | - | - | ↑ | - | - | - | - | - | ↑ | - | - |
| Atopic and NAR | - | - | - | - | - | NS (↑) | - | - | - | - | - | - | - | - | - | - | NR (↓) | - | - |
Values are presented as Mean (SD) or as Median (Interquartil Range), otherwise indicated: *Median (Range), †Mean (Range), ‡ Dispersion Measure not presented, §The studies' reports do not included numerical results. ||Comparison was based in a ratio between FeNO values in each group: 1, 2 or 3 arrows means a ratio increase/decrease on FeNO values of 1,2 or 3 or more times, respectively. DS: During Season OS: Out of Season. Adult classification was defined as a mean/median age value ≥18 years. Atopic was defined as presence of allergic sensitization without asthma and without rhinitis. All comparisons are statistically significant (p < 0.05), otherwise indicated. NR: Statistical significance not reported. NS: Not significant.