Table 2.

Selected SNP Candidates for Lumbar Disc Degeneration

Gene	SNP*	Chromosome	Location	Minor/Major Allele	References
AGC1	rs1042631	15q26.1	Exon (L2141L)	T/C	[26]
AGC1	rs1516797	15q26.1	Intron	G/T	[26]
VDR	rs10735810	12q13.11	Exon (M162T)	C/T	[37] [70]
VDR	rs731236	12q13.11	Exon (I352I)	C/T	[37] [70]
COL1A1	rs2075555	17q21.33	Intron	A/C	[26] [29]
COL2A1	rs917055	12q13.11	Intron	T/C	[26]
COL3A1	rs2056156	2q32.2	Intron	C/T	[26]
COL9A1	rs696990	6q13	Intergenic	G/A	[26]
COL9A2	rs7533552	1p34.2	Exon (Q326R)	G/A	[26] [30] [31]
COL9A3	rs61734651	20q13.33	Exon (R103W)	C/T	[32] [33]
COL11A1	rs1463035	1p21.1	Intron	G/A	[26]
COL11A1	rs1676486	1p21.1	Exon (S1535P)	A/G	[34]
COL11A2	rs2072915	6p21.32	Upstream	T/A	[26]
IL1A	rs2071375	2q13	Intron	A/G	[26] [42]
IL18R1	rs2287037	2q12.1	Upstream	A/G	[26]
IL18RAP	rs1420100	2q12.1	Intron	T/G	[26]
IL18RAP	rs1420106	2q12.1	Upstream	T/C	[26]
IL18RAP	rs917997	2q12.1	Downstream	A/G	[26]
MMP3	rs72520913	11q22.2	Upstream	-/A	[38]
COX2(PTGS2)	rs5277	1q31.1	Exon (V102V)	C/G	[43]
PTGS2(COX2)	rs4140564	1q31.1	Upstream	C/T	[49]
CALM1	rs12885713	14q32.11	5’UTR	C/T	[47]
DVWA	rs11718863	3p25.1	Exon	T/A	[48]
DVWA	rs7639618	3p25.1	Exon	T/C	[48]
FZRP	rs288326	2q32.1	Exon (R200W)	A/G	[46]
FZRP	rs7775	2q32.1	Exon (R324G)	G/C	[46]
GDF5	rs143383	20q11.22	5’UTR	C/T	[48]

^*Single-nucleotide polymorphism.