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. Author manuscript; available in PMC: 2012 Apr 30.
Published in final edited form as: J Comp Neurol. 2009 Mar 1;513(1):51–68. doi: 10.1002/cne.21944

Figure 2. Expression of SPRR1A in spinal cord and DRG following injury to the central projections of DRG neurons.

Figure 2

In the mouse cervical spinal cord one week after unilateral dorsal root crush injury (A, open arrow points to crush site) SPRR1A is expressed in some regenerating axons in the injured dorsal root as they approach the dorsal root entry zone (demarcated by dashed line), in some fibres within the ipsilateral spinal cord and in a small number of cells in the ipsilateral DRG (arrows point to 4 immunopositive neurons in the attached DRG); no positive immunofluorescence for SPRR1A is observed in the contralateral DRG. One week after a T12 thoracic dorsal column crush injury (B-E), only a few fine fibres are observed in the superficial dorsal horns (B) at the level of the lesion and virtually no SPRR1A immunofluorescence is apparent in the lumbar DRG; arrows point to the single immunopositive neuron observed in an entire section of the L4 (C) and L5 (D) DRG, and no positive cells are apparent in the L6 DRG (E). Scale bar = 500 um (A,B), 400 um (C-E).