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. Author manuscript; available in PMC: 2012 Apr 30.
Published in final edited form as: J Comp Neurol. 2009 Mar 1;513(1):51–68. doi: 10.1002/cne.21944

Figure 3. Time course and cell size distribution of SPRR1A expression in lumbar DRG following crush or transection of the sciatic nerve.

Figure 3

Following sciatic nerve crush (A) or transection (B) the time course of SPRR1A expression in L4/5 DRG neurons follows a similar pattern, becoming apparent by 1 day post lesion, rising to maximal levels by day 7 and then decreasing. However, at the earliest time point examined (1 d) SPRR1A expression is greater in the DRG of crush injured mice compared to transection. Conversely, at the latest time point examined (30 d), while SPRR1A expression is virtually absent in the DRG of crush injured mice it remains elevated following transection. Cell size distributions of SPRR1Aimmunopositive cells (SPRR1A +ve) compared to all cells in the L4 and L5 DRG (all cells) at the time point of maximal expression (7 d) reveal that a high proportion of cells in all size ranges are SPRR1A + ve following sciatic nerve crush (C) or transection (D). Cumulative frequency size distributions confirm no significant differences in the cell size distributions of SPRR1A+ve neurons compared to all neurons 7 days after sciatic nerve crush (E) or transection (F) (two-sample Kolmogorov-Smirnov test, P > 0.05).