Table II.
Blood-glucose insulin-dose-rate data analysis for patients in the Vanderbilt University Hospital Intensive Care Unit between May 31, 2004 and December 31, 2005. We display adjusteda point estimates and 95%CI corresponding to 3.0 U/h changes in insulin dose rate, 1.0 mg/dl change in the lagged response value, and 3.0 U/h changes in lagged insulin dose rate.
| Outcome/model | Covariate | Estimation strategy
|
||
|---|---|---|---|---|
| NS | LVS | LCS | ||
| Blood glucose, Yij | ||||
| 1a | Insulin rate | 6.0 (2.7, 9.5) | −24.0 (−32.5, −14.2) | −1.1 (−12.1, 11.5) |
| 1b | Insulin rate | −17.9 (−22.3, −13.6) | −23.2 (−30.6, −16.2) | −20.5 (−35.5, −6.6) |
| Glucose lag | 0.6 (0.5, 0.7) | 0.7 (0.5, 0.9) | 0.6 (0.4, 0.8) | |
| 1c | Insulin rate | 9.5 (5.5, 13.7) | −23.3 (−32.6, −14.9) | 1.2 (−11.4, 18.3) |
| Insulin rate lag | −5.4 (−8.7, −2.2) | −1.1 (−10.3, 8.1) | −4.4 (−15.5, 6.0) | |
| Blood glucose change, Zij | ||||
| 2a | Insulin rate | −33.1 (−37.2, −29.3) | −22.8 (−30.8, −15.7) | −31.5 (−45.3, −17.0) |
| 2b | Insulin rate | −17.9 (−22.3, −13.6) | −23.2 (−30.6, −16.2) | −20.5 (−35.5, −6.6) |
| Glucose lag | −0.4 (−0.5, −0.3) | −0.3 (−0.5, −0.1) | −0.4 (−0.6, −0.2) | |
| 2c | Insulin rate | −43.2 (−47.2, −39.1) | −20.4 (−35.6, −7.5) | −32.7 (−53.8, −14.9) |
| Insulin rate lag | 15.8 (12.1, 19.3) | −4.1 (−18.9, 11.2) | 2.8 (−11.8, 20.4) | |
NS, naïve strategy; LVS, lagged glucose value strategy; LCS, lagged glucose change strategy.
a
Section 2.2 of the text provides a list of adjustment variables included in all regression models.