Table 2.
Zonal analysis comparing the mean and variance of IGVs for male African and Caucasian Americansa
| Number of glomeruli measured | Mean IGV (×106 μm3) | IGV variance (×106 μm3) | |||||
| Group | Zone | ||||||
| CA | AA | CA | AA | CA | AA | ||
| Race (n = 75) | S | 340 | 410 | 4.03 | 4.88b | 2.74 | 3.38b |
| M | 340 | 410 | 4.38 | 5.20b | 3.57 | 3.66 | |
| J | 340 | 410 | 4.28 | 5.16b | 2.61 | 4.15b | |
| Cardiovascular | NT | HTN | NT | HTN | NT | HTN | |
| AA (n = 41) | S | 160 | 250 | 4.23 | 5.29b | 2.60 | 3.46b |
| M | 160 | 250 | 4.56 | 5.61b | 2.30 | 4.11b | |
| J | 160 | 250 | 4.42 | 5.63b | 1.95 | 4.99b | |
| CA (n = 32) | S | 170 | 150 | 3.56 | 4.69b | 1.51 | 3.65b |
| M | 170 | 150 | 3.86 | 5.11b | 2.45 | 4.27b | |
| J | 170 | 150 | 4.00 | 4.70b | 1.95 | 3.22b | |
| Metabolic | Lean | Obese | Lean | Obese | Lean | Obese | |
| AA (n = 22) | S | 80 | 140 | 4.72 | 4.56 | 2.52 | 3.54b |
| M | 80 | 140 | 4.96 | 5.17 | 4.28b | 3.20 | |
| J | 80 | 140 | 4.56 | 5.21c | 3.84 | 3.56 | |
| CA (n = 26) | S | 110 | 150 | 3.85 | 4.10 | 1.85 | 2.62b |
| M | 110 | 150 | 3.83 | 4.81b | 1.17 | 3.90b | |
| J | 110 | 150 | 3.71 | 4.61b | 1.42 | 2.48b | |
| CKD comorbidities (n = 15) | Low | High | Low | High | Low | High | |
| S | 70 | 80 | 3.33 | 4.78b | 1.05 | 2.90b | |
| M | 70 | 80 | 3.24 | 5.41b | 0.68 | 2.22b | |
| J | 70 | 80 | 3.44 | 5.21b | 1.08 | 2.70b |
a
Group definitions: AA (African Americans), CA (Caucasian Americans), NT (mormotensive), HTN (hypertensive), lean (BMI ≤24.9 kg/m2), obese (BMI ≥30.0 kg/m2), low (age ≤30 years + BMI ≤29.9 kg/m2 + normotensive) and high (age ≥40.0 years + BMI ≥30.0 kg/m2 + hypertensive). Zones: S (superficial), M (middle) and J (juxtamedullary). Numbers indicted in bold type are statistically significant.
b
P < 0.001 between comparable groups and within the same zone.
c
P < 0.05 between comparable groups and within the same zone.