Table 4.
Coefficients and p-values of multivariate linear regression models of ln-transformed urinary mercury predicted against exposure surrogates of elemental mercury, MT1M [3´ UTR (G > A); rs2270837] genotype, and exposure–MT1M interactions.
| Exposure | β-Coefficient | p-Value | ||
|---|---|---|---|---|
| Base model (R2 = 0.25) | ||||
| Intercept | –0.70 | |||
| Personal amalgams | 0.085 | < 0.0001 | ||
| Amalgams handled/week | 0.11 | 0.04 | ||
| Nondentist | –0.38 | 0.001 | ||
| SNP main effects | ||||
| Heterozygote | –0.04 | 0.87 | ||
| Homozygote variant | 1.85 | 0.008 | ||
| SNP–exposure interaction | ||||
| Personal amalgams × heterozygote | –0.002 | 0.92 | ||
| Amalgams handled × heterozygote | 0.11 | 0.32 | ||
| Nondentist × heterozygote | –0.03 | 0.90 | ||
| Personal amalgams × homozygote variant | –0.25 | 0.02 | ||
| Amalgams handled × homozygote variant | –0.97 | 0.01 | ||
| Nondentist × homozygote variant | –0.06 | 0.94 | ||