Table 5.

Coefficients and p-values from multivariate linear regression models of ln-transformed hair mercury predicted by estimated MeHg exposure, SNP genotype, and intake–SNP interactions.

MT1M 3´ UTR (T > C; rs9936741; R2 = 0.20)			MT1A missense (A > G; rs8052394; R2 = 0.21)
β-Coefficient	p-Value	β-Coefficient	p-Value
Base model
Estimated daily MeHg intake		3.69		< 0.0001		4.04		< 0.0001
SNP main effects
Heterozygote		–0.03		0.92		0.21		0.40
Homozygote variant		—a		—a		—b		—b
SNP–intake interactions
Intake × heterozygote		19.3		0.02		–300		0.02
Intake × homozygote variant		—a		—a		—b		—b
aThe homozygote variant number was zero for MT1M (rs9936741). bBecause the number of homozygote variants for MT1A (rs8052395) was too small (n = 1), it was lumped with the heterozygote variant in testing interaction.