Table 1.

Role of AhR in pro- and anti-inflammatory gene regulation in hMADS precursors and adipocytes: fold induction after treatment (mean ± SE).

Gene	DMSO	α-NF	TCDD	TCDD + α-NF	PCB-126	PCB-126 + α-NF
Precursor cells
CYP1B1		1.01 ± 0.10		2.01 ± 0.21		9.29 ± 1.42		3.70 ± 0.65*		9.67 ± 1.61		4.61 ± 0.97*
IL1B		1.04 ± 0.18		1.84 ± 0.24		11.09 ± 1.11		3.04 ± 0.36*		8.93 ± 1.15		3.14 ± 0.27*
IL8		1.04 ± 0.21		1.64 ± 0.33		4.10 ± 0.82		1.93 ± 0.38*		4.18 ± 1.29		2.09 ± 0.13*
MCP1		1.01 ± 0.09		1.16 ± 0.14		2.62 ± 0.13		1.32 ± 0.21*		2.53 ± 0.12		1.33 ± 0.24*
PAI2		1.03 ± 0.17		2.01 ± 0.39		21.18 ± 4.40		2.92 ± 0.45*		14.98 ± 3.77		4.29 ± 0.78*
PTGS2		1.00 ± 0.03		1.43 ± 0.07		6.75 ± 1.29		2.29 ± 0.10*		5.78 ± 0.24		2.69 ± 0.31*
IL1ra		0.97 ± 0.29		1.54 ± 0.18		2.58 ± 0.66		1.01 ± 0.04*		2.21 ± 0.25		1.26 ± 0.13*
Adipocytes
CYP1B1		1.03 ± 0.17		0.72 ± 0.09		7.16 ± 1.67		1.89 ± 0.11*		6.94 ± 1.46		2.70 ± 0.60*
IL1B		1.04 ± 0.20		0.93 ± 0.07		1.00 ± 0.19		1.21 ± 0.18		1.31 ± 0.27		1.28 ± 0.16
IL8		1.02 ± 0.14		0.81 ± 0.16		1.81 ± 0.20		0.93 ± 0.11*		2.26 ± 0.96		1.25 ± 0.29
MCP1		1.07 ± 0.29		0.92 ± 0.07		1.88 ± 0.26		1.12 ± 0.16*		1.57 ± 0.32		1.16 ± 0.16
PAI2		1.01 ± 0.09		0.55 ± 0.16		3.93 ± 0.44		1.64 ± 0.33*		4.83 ± 0.52		2.30 ± 0.66*
PTGS2		1.03 ± 0.19		0.84 ± 0.10		1.63 ± 0.38		1.00 ± 0.12		2.07 ± 0.30		1.14 ± 0.02*
IL1ra		1.00 ± 0.05		1.09 ± 0.25		0.96 ± 0.00		1.23 ± 0.12		1.14 ± 0.01		1.35 ± 0.31
Gene expression was normalized by HPRT expression in undifferentiated cells and by TBP expression in adipocytes. *p < 0.05, For TCDD-treated or PCB-126–treated cells without versus with pretreatment with α-NF, by Mann–Whitney U-test.