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. 2012 Jan 3;120(4):583–589. doi: 10.1289/ehp.1104580

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Stable knockdown of NRF2 in HaCaT cells reduces expression of KEAP1 but augments iAs³⁺-induced protein accumulation of long isoforms of NRF1. (A, B) Concentration response of mRNA (A) and protein (B) expression of KEAP1 and NRF1 in NRF2-KD and SCR cells exposed to various concentrations of iAs³⁺ or vehicle (medium) for 6 hr. (C, D) Time course of mRNA (C) and protein (D) expression of KEAP1 and NRF1 in NRF2-KD and SCR cells in response to 10 μM iAs³⁺ or vehicle. Integers in parentheses after gene names in A and C are cross-threshold PCR cycle numbers in SCR cells treated with vehicle. *p < 0.05 versus SCR with the same treatment.