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(Left) Sttotal from Definity oscillating in a 3.15 MHz field and PD of 5 cycles for an ED of 30 s for selected radii sizes (0.5, 1.0, 1.5, and 2.0 μm). Pr was varied between 0 and 3 MPa. (Right) The weighted sum of Sttotal for all radii of Definity at the same exposure conditions. The circle located at 0.26 MPa represents the pressure at which the maximum sonoporation activity occurred under experimental conditions (Ref. 8).
