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. 2012 Apr 19;117(2):113–121. doi: 10.3109/03009734.2012.658976

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Figure 1. — Putative glioma cell of origin and its role for glioma development. A: A simplified schematic representation of glial cell development from the multipotent CNS stem cell into astrocytes and oligodendrocytes, where each stage is defined by the expression of markers. Red lightings indicate the occurrence of an oncogenic event that will induce glioma development. B: The role of cellular origin for glioma initiation, progression, recurrence and response to therapy remains largely unknown. The search for biomarkers that could distinguish phenotypically distinct glioma subgroups based on cell of origin could be one path towards elucidating this matter. NSC = neural stem cell; GRPC = glial restricted progenitor cell; APC = astrocyte precursor cell; OPC = oligodendrocyte precursor cell.