Table I.
Mouse models with confirmed or candidate cell of origin for glioma.
| Cell of origin | Promoter | Deleted or inactivated genes | Overexpressed or activated genes | Ref |
|---|---|---|---|---|
| Astrocyte | NA | p16Ink4a and p19Arf | Mutant EGFR | (29) |
| GFAP | v-Src | (30) | ||
| GFAP | Ha-Ras | (31) | ||
| GFAP | pRb, p107, p130 | (32) | ||
| GFAP (RCAS-tv-a) | PDGF-B | (21) | ||
| Neural stem or progenitor cell | Nestin-CreERT2 | Nf1, p53, and/or Pten | (63) | |
| GFAP-Cre | H-Ras and Akt | (24) | ||
| Nestin (RCAS-tv-a) | K-Ras and Akt | (64) | ||
| NA | p16Ink4a and p19Arf | Mutant EGFR | (29) | |
| Oligodendrocyte precursor cell | NA | p53 | Ras | (74) |
| CNP (RCAS-tv-a) | PDGF-B | (8) | ||
| S100β | Mutant EGFR | (6) | ||
| GFAP-Cre or Nestin-Cre | Nf1 and p53 | (7) |
NA = not applicable.