Table 2. Comparisons of sCD14 and sCD23 Levels in Glioma Cases and Controls, San Francisco Bay Area Adult Glioma Study (1997-2006).

			Cases		Controls
Value	Case Category		n	Mean ± SE	n	Mean ± SE	t-test p-value**
sCD14	All		1078	10.3 ± 0.13 ug/mL	736	8.1 ± 0.09 ug/mL	<0.01
sCD23	All		1064	2.7 ± 0.08 ng/mL	727	3.6 ± 0.13 ng/mL	<0.01
Value	Category	Quartile	n	%	n	%	OR* (95% CI)	OR p-value*	Test for Trend
sCD14	All	1	174	16	184	25	1.00
		2	130	12	184	25	0.79 (0.58-1.08)	0.14
		3	195	18	184	25	1.21 (0.90-1.63)	0.21
		4	579	54	184	25	3.94 (2.98-5.21)	<0.01	P<0.01
	GBM	1	94	15	184	25	1.00
		2	66	11	184	25	0.71 (0.49-1.04)	0.08
		3	110	18	184	25	1.19 (0.84-1.69)	0.33
		4	347	56	184	25	4.02 (2.93-5.50)	<0.01	P<0.01
	Non-GBM	1	80	17	184	25	1.00
		2	64	14	184	25	0.90 (0.60-1.36)	0.61
		3	85	18	184	25	1.21 (0.81-1.79)	0.35
		4	232	50	184	25	3.88 (2.73-5.53)	<0.01	P<0.01
sCD23	All	1	437	41	183	25	1.00
		2	221	21	181	25	0.52 (0.40-0.68)	<0.01
		3	232	22	182	25	0.53 (0.41-0.69)	<0.01
		4	174	16	181	25	0.40 (0.31-0.53)	<0.01	P<0.01
	GBM	1	281	46	183	25	1.00
		2	129	21	181	25	0.47 (0.35-0.63)	<0.01
		3	117	19	182	25	0.41 (0.30-0.56)	<0.01
		4	82	14	181	25	0.29 (0.21-0.41)	<0.01	P<0.01
	Non-GBM	1	156	34	183	25	1.00
		2	92	20	181	25	0.62 (0.44-0.88)	<0.01
		3	115	25	182	25	0.75 (0.54-1.05)	0.09
		4	92	20	181	25	0.62 (0.43-0.88)	<0.01	P=0.02

^*Odds ratios were adjusted for age (continuous), race (white/non-white), gender, education (college vs no college), and smoking (ever vs never). ORs for the GBM and non-GBM groups were estimated using polytomous logistic regression models.

Note: sCD14 Quartile cutoff values were: (1) Quartile 1=1.45-6.49ug/mL, (2) Quartile 2=6.50-7.65 ug/mL, (3) Quartile 3=7.66-9.26 ug/mL, and (4) Quartile 4=9.27-37.14 ug/mL.

sCD23 Quartile cutoff values were: (1) Quartile 1=0.03-1.57ng/mL, (2) Quartile 2=1.58-2.59 ng/mL, (3) Quartile 3=2.61-4.41 ng/mL, and (4) Quartile 4=4.43-38.72 ng/mL.

^**T-test comparing sCD14/sCD23 means between cases and controls.

SE=Standard error