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. 2012 Mar 9;153(5):2420–2435. doi: 10.1210/en.2011-1783

Fig. 5.

Fig. 5.

Postischemia brain and spleen cytokine expression in control and VDD rats. Brain samples from the ischemic (left) hemisphere and nonischemic (right) hemisphere were collected at d 5 after MCAo and analyzed for cytokine/chemokine expression. A, Arrows indicate the direction of significant changes in expression in specific cytokines in VDD animals relative to controls (P ≤ 0.05). B, At 5 d after stroke, IL-6 levels were significantly higher in the ischemic cortex and striatum compared with the nonischemic side (b, Main effect of ischemia). Furthermore, VDD resulted in a greater elevation of IL-6 in both the cortex (1.21-fold) and striatum (1.51-fold) compared with controls (c, Interaction effect of diet treatment and ischemia). C, At 5 d after stroke, TGF-β1 levels were significantly higher in the ischemic cortex and striatum compared with the nonischemic side (b, Main effect of ischemia). Data were analyzed by two-way ANOVA for diet treatment and ischemia; for each region; b, Main effect of ischemia; c, interaction effect of diet treatment of ischemia. Group differences were considered significant at P ≤ 0.05. Bars represent mean ± sem; n = 4–7 in each group. GM-CSF, Granulocyte-macrophage colony stimulating factor.