Table 5.
Differentially expressed genes related to cancer*
| Gene symbol | Accession number | Gene name | Fold difference | P-value |
|---|---|---|---|---|
| Up-regulated in DA | ||||
| Oncogenes and tumorigenesis | DA/Cia10 | |||
| Rcl (C6ORF108) | NM_133525.1 | Nucleoside 2-deoxyribosyltransferase domain containing protein (RGD620382) | 2.38 | 0.004 |
| Kras | NM_031515.1 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 1.93 | 0.005 |
| Rbm3 | XM_001063211.1 | RNA binding motif (RNP1, RRM) protein 3 | 1.57 | 0.009 |
| Ikbke | XM_001058036.1 | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | 1.51 | 0.007 |
| St14 | NM_053635.2 | suppression of tumorigenicity 14 | 2.55 | 0.0004 |
| Cdc25a | NM_133571.1 | cell division cycle 25 homolog A | 1.67 | 0.007 |
| Hdac1 | XM_216349.3 | histone deacetylase 1 | 1.52 | 0.006 |
| Hdac2 | XM_342149.3 | histone deacetylase 2 | 1.53 | 0.0007 |
| Cell proliferation | ||||
| Mcts1 | XM_001064848.1 | malignant T cell amplified sequence 1 | 2.20 | 0.001 |
| Ppap2a | NM_022538.1 | phosphatidic acid phosphatase type 2A | 2.12 | 0.002 |
| Ier3 | NM_212505.1 | immediate early response 3 | 1.93 | 0.008 |
| Aplnr | NM_031349.2 | apelin receptor | 1.80 | 0.009 |
| Cell invasion | ||||
| Cd53 | NM_012523.1 | cluster of differentiation 53 | 3.28 | 0.004 |
| Loxl1 | NM_001012125.1 | lysyl oxidase-like 1 | 1.92 | 0.005 |
| Ctsd | NM_134334.2 | cathepsin D | 2.27 | 0.001 |
| Histone deacetylation | ||||
| Rbbp7 | NM_031816.1 | retinoblastoma binding protein 7 | 2.68 | 0.005 |
| Hdac2 | XM_342149.3 | histone deacetylase 2 | 1.53 | 0.001 |
| Hdac1 | XM_216349.3 | histone deacetylase 1 | 1.52 | 0.007 |
| Up-regulated in DA.ACI(Cia10) | ||||
| Inhibitors of cell proliferation and growth | Cia10/DA | |||
| Igfbp6 | NM_013104.2 | insulin-like growth factor binding protein 6 | 3.56 | 0.007 |
| Per1 | XM_340822.2 | period 1 | 2.78 | 0.001 |
| Thbd | NM_031771.2 | thrombomodulin | 1.96 | 0.002 |
| Pawr | NM_033485.2 | PRKC, apoptosis, WT1, regulator | 1.54 | 0.005 |
| Inhibitors of invasion | ||||
| Nov | NM_030868.2 | nephroblastoma overexpressed gene | 2.86 | 0.007 |
| Rgs4 | NM_017214.1 | regulator of G-protein signaling 4 | 2.05 | 0.008 |
| Tgfbr3# | NM_017256.1 | transforming growth factor, beta receptor III | - | - |
| Inhibitors of MMPs | ||||
| Timp2 | NM_021989.2 | tissue metallopeptidase inhibitor 2 | 2.15 | 0.002 |
| Reck | XM_001070551.1 | reversion-inducing-cysteine-rich protein with kazal motifs | 2.10 | 0.005 |
*
Some of these genes have more than a single cancer-related function.
#
Tgfbr3 was expressed by 6 (50%) DA and 6 (100%) DA.ACI(Cia10) synovial tissues. Tgfbr3 is also a suppressor of cancer growth and cell proliferation.