Table 1.
Pathway analysis of Microarray data showed 4 important pathways were regulated after 48 hours of FK506 treatment.
| Pathway | Regulated genes | FC | p-value |
|---|---|---|---|
| Cytoskeleton remodeling | Neuroepithelial cell-transforming gene 1 protein | 1.28 | 0.01 |
| Serine/threonine-protein kinase PAK 1 | 1.34 | <0.01 | |
| Platelet-derived growth factor A chain precursor | 0.72 | <0.01 | |
| Phosphatidylinositol 3-kinase regulatory subunit alpha | 1.28 | 0.01 | |
| Ras-related C3 botulinum toxin substrate 1 precursor | 1.49 | 0.02 | |
| T-lymphoma invasion and metastasis-inducing protein 1 | 0.6 | <0.01 | |
| Protein vav-2 | 1.4 | 0.04 | |
| Transport Membrane trafficking | Guanine nucleotide-binding protein G(i), alpha-2 subunit | 1.2 | <0.01 |
| Guanine nucleotide-binding protein subunit beta-4 | 0.37 | <0.01 | |
| Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit γ-12 prec. | 1.19 | 0.02 | |
| Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit γ-3 prec. | 0.56 | 0.01 | |
| Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit γ-7 prec. | 0.74 | <0.01 | |
| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 | 1.21 | <0.01 | |
| Rap1 GTPase-activating protein 1 | 1.34 | <0.01 | |
| G-protein signaling G-Proteins mediated regulation p38 and JNK signaling | B-cell linker protein | 2.23 | <0.01 |
| Guanine nucleotide-binding protein G(i), alpha-2 subunit | 1.21 | <0.01 | |
| Guanine nucleotide-binding protein subunit beta-4 | 0.37 | <0.01 | |
| Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit γ-12 prec. | 1.19 | 0.02 | |
| Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit γ-3 prec. | 0.56 | 0.01 | |
| Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit γ-7 prec. | 0.74 | <0.01 | |
| Dual specificity mitogen-activated protein kinase kinase 6 | 1.43 | <0.01 | |
| Mitogen-activated protein kinase 10 | 0.76 | 0.02 | |
| Serine/threonine-protein kinase PAK 1 | 1.33 | 0.02 | |
| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 | 1.21 | 0.001 | |
| Protein tyrosine kinase 2 beta | 1.99 | <0.01 | |
| Ras-related C3 botulinum toxin substrate 1 precursor | 1.49 | 0.02 | |
| Protein vav-2 | 1.4 | 0.04 | |
| ATP metabolism | Ectonucleotide pyrophosphatase/phosphodiesterase (member 2) prec. | 2.36 | <0.01 |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 | 1.63 | <0.01 | |
| Ectonucleoside triphosphate diphosphohydrolase 3 | 1.22 | 0.04 | |
| phosphodiesterase 10A | 0.36 | <0.01 | |
| cGMP-dependent 3′,5′-cyclic phosphodiesterase | 0.57 | <0.01 | |
| cGMP-inhibited 3′,5′-cyclic phosphodiesterase B | 1.31 | <0.01 | |
| cAMP-specific 3′,5′-cyclic phosphodiesterase 4B | 0.51 | <0.01 | |
| cAMP-specific 3′,5′-cyclic phosphodiesterase 4C | 0.76 | 0.03 | |
| phosphodiesterase 8A | 0.54 | 0.01 | |
| Tryptophanyl-tRNA synthetase, cytoplasmic | 1.18 | <0.01 |